Publications by authors named "Daniyal Nadeem"
Introduction: Psoriasis is a chronic skin condition characterized by hyperproliferation of epidermal keratinocytes, resulting in erythematous and scaling lesions. The US Food and Drug Administration (FDA) has approved nine biologic agents to address the burden of psoriasis, but their cardiovascular risks remain poorly studied.
Methods: This retrospective pharmacovigilance study utilized the FDA Adverse Event Reporting System (FAERS) database to analyze adverse events associated with newly approved therapeutic agents for psoriasis.
Article Synopsis
- Ulcerative colitis, a chronic inflammatory condition, can lead to impaired gut barrier function, prompting this study to evaluate the effects of a red algae-derived multi-mineral supplement (Aquamin) on barrier proteomic expression.
- Human colon organoids were cultured either in a control medium or exposed to inflammatory stimuli (LPS-cytokines), then treated with Aquamin for 14 days to assess its impact on protein expression related to gut barrier integrity.
- The results indicated that Aquamin reduced the expression of several inflammation-related proteins and enhanced the expression of proteins that support barrier formation, showing promise for improving gut health in inflammatory conditions.
Diabetic myonecrosis is an unpublicised problem that can occur in patients having either type 1 or type 2 diabetes mellitus. It usually affects patients who have long-standing, uncontrolled diabetes with associated microvascular complications. We report a case of a 78-year female with diabetic myonecroses admitted to a tertiary care hospital.
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- Aquamin, a natural multi-mineral product rich in calcium and magnesium, was studied to see if it could improve the colonic barrier in patients with ulcerative colitis (UC) by utilizing colonoid cultures from their biopsies.
- The study involved incubating these colonoids with or without Aquamin for two weeks, analyzing changes in barrier proteins and structure using advanced microscopy and proteomic techniques.
- Results showed some positive effects, including increased expression of differentiation-related proteins and tight junctions, as well as improved structural features, suggesting that Aquamin may enhance barrier function in UC-affected tissue.
Article Synopsis
- The study aimed to evaluate the effects of calcium and a multi-mineral product called Aquamin on the growth and differentiation of colonoid cultures from normal human colon tissue.
- Researchers maintained colonoid cultures in low-calcium and higher calcium conditions, analyzing growth, morphology, and protein expression after two weeks.
- Results showed that normal colonoids naturally differentiated even without calcium supplementation, while both calcium alone and Aquamin enhanced proteins related to tissue integrity, but had minimal additional effects on cell growth and differentiation.
Aim: To assess circulatory levels of interleukin-18 (IL-18) and determine whether the presence of IL-18 promoter polymorphism influences metabolic syndrome phenotypes.
Methods: This study recruited one hundred and eighty individuals divided into three groups with sixty subjects each as: Normal weight (18.0-22.