Pro-inflammatory Cytokines, Biomarkers, Genetics and the Immune System: A Mechanistic Approach of Depression and Psoriasis.

Objective: To highlight the inflammatory and immunological mechanisms involved in depression and psoriasis.

Methods: A comprehensive literature search was performed in various databases, in total 145 studies were selected.

Results: Depression and psoriasis have an association.

Major Depression and Psoriasis: A Psychodermatological Phenomenon.

Objective: The aim of this paper was to highlight the mechanisms involved and the relationship between depression and psoriasis.

Method: A comprehensive literature search was performed in various databases, and finally 88 studies were deemed relevant.

Results: A significant link was found between depression and psoriasis, primarily through immune mechanisms related but not limited to the actions of inflammatory cytokines such as tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8.