Publications by authors named "Danish Nasar Khan"
Background & Objectives: Presence of dengue is reported from India since 1960s. Secondary dengue infection may be more severe than primary, hence, distinction between primary and secondary dengue is essential. A way to detect secondary dengue is demonstration of anti DV IgG in patients' serum.
View Article and Find Full Text PDFPurpose: Hepatitis E virus (HEV) is responsible for >50% of acute viral hepatitis (AVH) in developing countries. It has 4 major genotypes and various subtypes which vary in geographical distribution, clinical manifestations and epidemiological patterns. This study was conducted to characterise HEV isolates from north India to study the effect of host and viral factors on HEV infection.
View Article and Find Full Text PDFSubacute sclerosing panencephalitis (SSPE) is still a common disease in India which is characterized by a progressive mental decline, myoclonus, periodic encephalographic abnormalities, and raised anti-measles antibody titter in the cerebrospinal fluid. Acute fulminant SSPE is characterized by a rapid course of disease culminating in death, within 6 months. We report of a 10-year-old boy, who came with a 14-day history of continuous involuntary jerky movements of the left half of the body, including the head.
View Article and Find Full Text PDFThe present study was planned to estimate the incidence of human Parvovirus B19 infection and understand its progression in children suffering with hematological malignancy. The circulating B19V genotypes and viral mutations occurring in strains of B19V over one-year period were also studied. Children with malignancies were enrolled consecutively and were followed up for one-year period.
View Article and Find Full Text PDFBackground & Objectives: The epidemiology of dengue fever (DF) is complex in the Indian subcontinent as all the four serotypes are circulating. This study reports observations on dengue cases from a virus diagnostic laboratory of a north Indian tertiary care hospital catering to areas in and around Lucknow, Uttar Pradesh.
Methods: Serum samples were obtained from suspected cases of dengue referred to the virus diagnostic laboratory during 2011 to 2013, and detailed history was taken on a pre-structured datasheet.
Article Synopsis
- Acute encephalitis syndrome (AES) is a serious health issue in eastern Uttar Pradesh, resulting in thousands of deaths annually, with this study focusing on its viral causes and epidemiology near Lucknow.
- Analysis of cerebrospinal fluid samples from 1,578 AES patients revealed that Japanese encephalitis virus (JEV) and dengue virus (DV) were the most common viral triggers, with JEV accounting for 16.2% of cases.
- The study highlighted that JEV led to the highest mortality rates, while herpes simplex virus (HSV) resulted in significant long-term neurological disabilities; it underscores the need to consider multiple viral agents in AES diagnosis.
Objective: To report high co-positivity of anti-dengue virus (DV) and anti-Japanese encephalitis virus (JEV) IgM in an area endemic for both the viruses and to discuss the possibilities of co-infection.
Methods: Serum samples from the patients who presented with fever, suspected central nervous system infection and thrombocytopenia, were tested for anti-DV IgM and anti-JEV IgM antibodies. Conventional reverse transcriptase polymerase chain reaction was done for detection of DV RNA and JEV RNA.
Article Synopsis
- The text discusses two children diagnosed with acute left ventricular dysfunction due to dilated cardiomyopathy, needing inotropic support.
- Both patients were tested for various cardiotropic viruses using PCR methods and antibody testing.
- One child recovered completely without specific therapy, while the other was treated for parvovirus B19 and hypocalcemia, marking the first report of circulating genotype 3 of the virus from India.