Publications by authors named "Danish Abdus Samad"
Investigating the effect of vandetanib and celecoxib combination on angiogenesis.
J Taibah Univ Med Sci
October 2023
Article Synopsis
- Angiogenesis is crucial for tumor growth, and the study investigated how the drugs vandetanib and celecoxib affect this process using human umbilical vein endothelial cells (HUVECs).
- Both drugs, individually and in combination, decreased cell viability and increased apoptosis in HUVECs, with the combination showing the highest impact.
- The combination of vandetanib and celecoxib significantly inhibited angiogenic tube formation and reduced the expression of angiogenic genes MMP-2 and MMP-9 more effectively than either drug alone.