Publications by authors named "Danilo Norata"
Tregs for adoptive therapy are traditionally expanded ex vivo using high doses of IL-2. However, the final Treg product has limited survival once infused in patients, potentially affecting therapeutic effectiveness. Here, we tested a novel expansion protocol in which highly purified naïve Tregs were expanded with a combination of IL-7 and IL-15, in the absence of IL-2.
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- * RVX treatment significantly reduced inflammatory markers (IL-6, MCP-1, VCAM-1, and ICAM-1) in plasma and decreased the expression of related genes in the aorta after LPS exposure.
- * RVX also improved contractile dysfunction of aortic rings caused by LPS, highlighting its potential to alleviate acute vascular inflammation and related issues.
Progression of carotid vascular damage and cardiovascular events in non-alcoholic fatty liver disease patients compared to the general population during 10 years of follow-up.
Atherosclerosis
March 2016
Background And Aim: Non-alcoholic fatty liver disease (NAFLD) is associated not only with liver related morbidity and mortality but also with an increased risk of cardiovascular disease.
Aim: to evaluate in patients with NAFLD and in matched Controls after 10 years of follow-up 1 the incidence of major cardiovascular and cerebral events 2 the progression of vascular damage.
Methods: Clinical and cardio-metabolic data were collected in 125 NAFLD patients and 250 age and gender matched Controls at baseline and 10 years later.