Publications by authors named "Danilo Micali"
Article Synopsis
- Childhood maltreatment (CM) can affect the children of those who experienced it, and the biological processes behind this are not well understood.
- This study examined how maternal experiences of CM relate to the expression of microRNAs (miRNAs) in maternal and perinatal tissues by analyzing samples from 43 pregnant women.
- It found that higher levels of maternal CM were linked to lower levels of a specific miRNA (hsa-miR-582-3p) in cord blood, suggesting a potential impact on the genetic development of the offspring.
Introduction: Long interspersed nuclear elements (LINEs) are endogenous retrotransposable elements. A few studies have linked the methylation pattern of LINE-1 to different mental disorders (e.g.
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- The protein Sirtuin-1 (SIRT1) was observed to increase in response to stress and was linked to DNA damage repair and modifications in the genome that promote melanoma progression.
- Silencing SIRT1 resulted in increased expression of genes associated with tumor growth and aggressiveness, highlighting its role in malignant transformation during stressful conditions.