Publications by authors named "Danika M Tumbleson-Brink"
Hum Mol Genet
November 2016
Article Synopsis
- Trisomy 21 (Down syndrome) leads to craniofacial abnormalities that impact breathing, eating, and speaking due to neural crest cell deficiencies.
- Researchers used mouse models to explore the role of Dyrk1a, a gene present in three copies in individuals with Down syndrome, in shaping these craniofacial features.
- Treatment with a Dyrk1a inhibitor and normalizing Dyrk1a levels showed promise in improving some craniofacial traits, suggesting that targeted prenatal therapies could help address certain anatomical issues associated with Down syndrome.
