Publications by authors named "Danijela Vasiljevic"
Background: The present study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. Non-invasive masks cannot completely prohibit head movements. Previous studies attempted to estimate the magnitude of intrafractional inaccuracy by means of pre- and postfractional measurements only.
View Article and Find Full Text PDFAim: of this study is to determine the temporal resolution of therapy-induced pneumonitis, and to assess promoting factors in adjuvant treated patients with unilateral mammacarcinoma.
Patients And Methods: A total of 100 post-surgery patients were recruited. The cohort was treated by 2 field radiotherapy (2FRT; breast and chest wall, N = 75), 3 field radiotherapy (3FRT; + supraclavicular lymphatic region, N = 8), or with 4 field radiotherapy (4FRT; + parasternal lymphatic region, N = 17).
A domestic porcine model for studying the effects of radiation on head and neck cancers.
Oral Surg Oral Med Oral Pathol Oral Radiol
May 2017
Background: Radiation therapy (RT) of the head and neck region is often accompanied by serious side effects. Research in this area is needed to improve treatment outcomes and ameliorate therapy tolerance. Laboratory rodents are barely matching today's clinical standards in RT research.
View Article and Find Full Text PDFRationale: The neuropeptide catestatin is an endogenous nicotinic cholinergic antagonist that acts as a pleiotropic hormone.
Objective: Catestatin shares several functions with angiogenic factors. We therefore reasoned that catestatin induces growth of new blood vessels.
Article Synopsis
- Secretoneurin, a neuropeptide that promotes blood vessel formation and is responsive to low oxygen levels, was studied for its potential in improving angiogenesis for therapeutic purposes.
- Researchers created a gene therapy vector for secretoneurin and tested it in a mouse model with blood flow issues in the hindlimb, leading to significant improvements in muscle function, reduced tissue damage, and increased blood flow.
- The study concluded that secretoneurin gene therapy works by enhancing blood vessel formation and relies on nitric oxide to mediate its beneficial effects on angiogenesis and vascular growth.
Several members of the neuropeptide family exert chemotactic actions on blood monocytes consistent with neurogenic inflammation. Furthermore, chromogranin A (CgA) containing Alzheimer plaques are characterized by extensive microglia activation and such activation induces neuronal damage. We therefore hypothesized that the catecholamine release inhibitory peptide catestatin (hCgA(352-372)) would induce directed monocyte migration.
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