Dihydrosamidin: the basic khellactone ester derived from and its impact on neurotrophic factors, energy and antioxidant metabolism after rat cerebral ischemia-reperfusion injury.

Dihydrosamidin (DHS), a khellactone 3'--isovaleroyl-4'--acetyl ester, is naturally found in Apiaceae plants yet remains underexplored in biomedical research. Employing HPLC-PDA-MS analysis, the profiling of coumarins in revealed its significant presence, reaching DHS concentrations of 95 mg/g. DHS administering at a dosage of 80 mg/kg during bilateral transient occlusion of the common carotid artery in Wistar rats prevented neuronal death and decreased neuron-specific enolase levels in the blood serum, increases neurotrophic factors and vascular endothelial growth factor A levels in brain lysate.

Chemodiversity of Arctic Plant : LC-MS Profile and Antioxidant Activity.

Yuz. is a perennial evergreen shrub from the Rosaceae family. thrives in subalpine and subarctic regions, as well as in highlands spanning from Central Asia to Siberia and Mongolia.

Metabolites of and : Diversity and α-Glucosidase Inhibitory Potential.

α-Glucosidase inhibitors are essential in the treatment of diabetes mellitus. Plant-derived drugs are promising sources of new compounds with glucosidase-inhibiting ability. The Jacq.

Hogweed Seed Oil: Physico-Chemical Characterization, LC-MS Profile, and Neuroprotective Activity of Nanosuspension.

The seeds of dissected hogweed ( Ledeb., Apiaceae) are the source of hogweed oil (HSO), which is still underexplored and requires careful chemical and biological studies. The performed physico-chemical analysis of HSO elucidated basic physical characteristics and revealed the presence of fatty acids, essential oil components, pigments, and coumarins.

New Polysaccharides: Characterization and Anticomplementary Activity of Mycelium Polymers.

is a small genus of xylotrophic basidiomycetes and a source of bioactive fungochemicals among which a special place is occupied by polymeric compounds. In this study, polysaccharides that are widespread in Europe, Asia, and North America and a poorly understood fungal species, (Pers.) Karst.

Coumarins of Lovage Roots ( W.D.J.Koch): LC-MS Profile, Quantification, and Stability during Postharvest Storage.

Lovage ( W.D.J.

Caucasian Blueberry: Comparative Study of Phenolic Compounds and Neuroprotective and Antioxidant Potential of Vaccinium myrtillus and Vaccinium arctostaphylos Leaves.

(1) Background: Two Caucasian blueberries L. and L. are famous berry bushes growing in the Caucasus region and used to treat neurological diseases, but the chemistry and bioactivity of leaf extracts are still poorly studied.

Marigold Metabolites: Diversity and Separation Methods of Genus Phytochemicals from 1891 to 2022.

Marigold (), an important asteraceous genus, has a history of many centuries of therapeutic use in traditional and officinal medicines all over the world. The scientific study of metabolites was initiated at the end of the 18th century and has been successfully performed for more than a century. The result is an investigation of five species (i.

Protective effects of () on the brain mitochondrial function in white rats at hypoxia/reoxygenation.

Protective effects of (L.) Holub ( (L.) DC.

The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of (): A Comprehensive Review.

(L.) DC. (.

Polymeric Compounds of Lingonberry Waste: Characterization of Antioxidant and Hypolipidemic Polysaccharides and Polyphenol-Polysaccharide Conjugates from Press Cake.

Lingonberry ( L.) fruits are important Ericaceous berries to include in a healthy diet of the Northern Hemisphere as a source of bioactive phenolics. The waste generated by the processing industry is hard-skinned press cake that can be a potential source of dietary fiber and has not been studied thus far.

Caucasian Dragonheads: Phenolic Compounds, Polysaccharides, and Bioactivity of and .

Steven and L. are unexplored species of the genus (Lamiaceae family) with a distribution in the Caucasus, where they are used in folk medicine and local cuisine. There are no data on the chemical composition of these species.

metabolites and bioactivity: HPLC-PDA-ESI-tQ-MS/MS profiles, HPLC-UV quantification of and and choleretic potential.

is a small gentianaceous genus with a known ethnopharmacological focus as hepatoprotectors containing two underestimated species that are scientifically unexplored: (Grossh.) Toyok., which is typical of the Far East, and (Klotzsch) Ikonn.

Investigation of phenolic compounds at the leaves and shoots spp. and their antioxidant and antityrosinase activities.

Comparative phytochemical and pharmacological analysis of leaves and shoots of (L.) Spreng. and endemic of Transcaucasia and North Caucasia Lipsch.

Antioxidant Activity of Styrylpyrones from Inonotus rheades (Agaricomycetes) Mycelium under Oxidative Stress in Thellungiella salsuginea Cell Suspension Culture.

This study examined effects of the styrylpyrone fraction from mycelium of hymenochaetoid species, Inonotus rheades (Agaricomycetes), on reactive oxygen species inhibition in Thellungiella salsuginea cell culture under oxidative stress. We identified antioxidant effects of styrylpyrones from I. rheades mycelium on oxidative stress in T.

Metabolites of Prickly Rose: Chemodiversity and Digestive-Enzyme-Inhibiting Potential of and the Main Ellagitannin Rugosin D.

Prickly rose ( Lindl.) is the most distributed rose species in the Northern Hemisphere, used by indigenous people for various food purposes. The lack of detailed information about the chemical composition of has led us to study the phytochemical composition and metabolic profile of prickly rose extracts using chromatographic techniques.

Metabolites of Siberian Raspberries: LC-MS Profile, Seasonal Variation, Antioxidant Activity and, Thermal Stability of Phenolome.

H. Lev. & Vaniot, a famous Siberian shrub of the Rosaceae family, is used in the folk medicine of nomads (Buryats, Yakuts, Soyots, and Mongols) as a remedy for the treatment of diseases of the respiratory and hepatobiliary systems.

and Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress.

In modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e.

Water-Soluble Melanoidin Pigment as a New Antioxidant Component of Fermented Willowherb Leaves ().

Willowherb ( L., family Onagraceae) is a well-known food and medicinal plant used after fermentation as a source of beverages with high antioxidant potential. Despite this long history of use, only a few papers have described the chemical profile and bioactivity of fermented willowherb tea in general.

Antihypoxic activity of the dry extract from .

The antihypoxic effect of the Nepeta multifida L. dry extract was studied in experiments on white Wistar rats. The life span of animals was determined against the background of acute hypoxias: hypercapnic, hemic, and histotoxic ones.

Sagan Dalya Tea, a New "Old" Probable Adaptogenic Drug: Metabolic Characterization and Bioactivity Potentials of Leaves.

Adams' rhododendron ( Rehder) or Sagan Dalya tea is a famous Siberian evergreen medical plant of the Ericaceae family used in traditional medicines of Buryats, Yakuts, and Mongols as a tonic, stimulant, and adaptogenic drug. The high popularity of coupled with poor scientific knowledge prompted the addressing of gaps related to metabolic and biomedical data of Sagan Dalya tea. The application of solid-phase extraction and liquid chromatography-mass spectrometric techniques for the metabolomic study of leaf extracts resulted in the identification of more than 170 compounds, including carbohydrates, organic acids, simple phenol glycosides, triterpene glycosides, flavonoids, prenylated phenols, benzoic acid derivatives, hydroxycinnamates, dihydrochalcones, catechins, and procyanidins, most of which were identified for the first time in the plant.

Synanthropic Plants as an Underestimated Source of Bioactive Phytochemicals: A Case of (Lamiaceae).

Hemp nettle ( Boenn.) is a synanthropic species of the Lamiaceae family that is widely distributed across Europe, Asia, and Siberia. is deeply embedded in the ethnomedical tradition of Asian healers; however, this plant is still poorly characterized, both chemically and pharmacologically.

Phenolome of Asian Agrimony Tea ( Juz., Rosaceae): LC-MS Profile, α-Glucosidase Inhibitory Potential and Stability.

Functional beverages constitute the rapidly increasing part of the functional food section and represent an area with a wide range of products including herbal-based beverages. We carried out screening investigations of the extracts of 85 Rosaceous tea plants. Among the extracts analyzed herb extract demonstrated the highest inhibitory activity against the enzyme α-glucosidase (20.

Fruit Metabolites: Variation of LC-MS Profile and Antioxidant Potential during Ripening and Storage.

Weston or creamy strawberry is one of the less-known species of the genus (Rosaceae family) with a wide distribution in Eurasia and is still in the shadow of more popular relatives (garden strawberry) or (wild strawberry). Importantly, there is a lack of scientific knowledge on compounds, their stability in the postharvest period, and bioactivity. In this study, metabolites of fruits in three ripening stages were characterized with high-performance liquid chromatography with photodiode array and electrospray ionization triple quadrupole mass spectrometric detection (HPLC-PAD-ESI-tQ-MS).