Publications by authors named "Danielle Sword"
Objectives: RE-TELL is a qualitative study, which aims to understand patient, support person, clinician and coordinator experiences and perspectives of chimeric antigen receptor (CAR) T-cell therapy, to inform design of a clinical CAR T-cell service in Aotearoa New Zealand.
Design: Semistructured qualitative interviews focused on domains of: experience through treatment, elements that work well and those that could be improved on. Interviews used thematic analysis to identify key themes.
Objective: The minor allele (A) of the rs373863828 variant (p.Arg457Gln) in CREBRF is restricted to indigenous peoples of the Pacific islands (including New Zealand Māori and peoples of Polynesia), with a frequency of up to 25% in these populations. This allele associates with a large increase in body mass index (BMI) but with significantly lower risk of type-2 diabetes (T2D).
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- The study investigates how the A allele of the rs373863828 gene affects insulin release and sensitivity in overweight/obese men of Māori and Pacific ancestry, particularly its relationship with body mass index (BMI) and diabetes risk.
- Results indicate that men with the A allele have a greater increase in plasma insulin after meals, but this does not impact their insulin sensitivity or glucose disposal rates.
- The findings suggest that the A allele could contribute to a reduced risk of type 2 diabetes by enhancing insulin release without compromising insulin sensitivity.