Publications by authors named "Danielle Sutherby"
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- Lupus nephritis is a serious illness where the body's defense system attacks the kidneys, and current treatments don't work very well and can be harmful.
- Researchers looked at kidney samples from people with lupus nephritis and healthy people to understand what’s happening at a cellular level and found many different immune cell types involved in the disease.
- They discovered that certain immune cells were active and may play a big role in moving around the body, and they also learned that testing urine could help doctors understand kidney conditions without needing to do more painful tests.
Background: Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership RA/SLE Network aims to deconstruct autoimmune pathology by examining cells within target tissues through multiple high-dimensional assays. Robust standardized protocols need to be developed before cellular phenotypes at a single cell level can be effectively compared across patient samples.
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