Publications by authors named "Danielle Rogner"
Article Synopsis
- - The MDHHgermany registry was created to gather information on the experiences of individuals with Darier's disease (DD) and Hailey-Hailey disease (HH), focusing on treatment effectiveness and overall healthcare experiences.
- - A study involving 47 DD patients revealed that symptoms like itch and pain were common, with a significant portion of patients reporting dissatisfaction with their treatments and a lack of effective systemic therapies.
- - The findings underscore the urgent need for improved treatment options and patient care, setting the stage for future research and clinical trials to address these unmet needs.
Background: Darier's disease (DD) is a genodermatosis caused by mutations of the ATP2A2 gene leading to disrupted keratinocyte adhesion. Recurrent episodes of skin inflammation and infections with a typical malodour in DD indicate a role for microbial dysbiosis. Here, for the first time, we investigated the DD skin microbiome using a metabarcoding approach of 115 skin swabs from 14 patients and 14 healthy volunteers.
View Article and Find Full Text PDFThe autosomal-dominant genodermatoses Darier disease and Hailey-Hailey disease present special challenges to dermatologists. Despite their similar pathogenesis featuring impaired adhesion of suprabasal keratinocytes as a result of defective ATPases in epidermal calcium channels, the two diseases differ considerably in clinical presentation and therapeutic options. Darier disease is characterized by reddish brown, keratotic papules in seborrheic and intertriginous areas, which may coalesce into extensive lesions.
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