Publications by authors named "Danielle Rastedt"
Article Synopsis
- Dopamine (DA) is crucial for functions related to reward, mood, movement, and attention, with its levels being regulated by the dopamine transporter (DAT) post-release.
- Imbalances in DA due to DAT dysfunction are linked to neurological disorders like schizophrenia, bipolar disorder, Parkinson's disease, and ADHD, making DAT a target for certain drugs.
- Recent research highlights how S-palmitoylation affects DAT activity and stability, suggesting that understanding this process could help find new treatments for disorders related to dopamine regulation.
The dopamine transporter is a neuronal protein that drives the presynaptic reuptake of dopamine (DA) and is the major determinant of transmitter availability in the brain. Dopamine transporter function is regulated by protein kinase C (PKC) and other signaling pathways through mechanisms that are complex and poorly understood. Here we investigate the role of Ser-7 phosphorylation and Cys-580 palmitoylation in mediating steady-state transport kinetics and PKC-stimulated transport down-regulation.
View Article and Find Full Text PDFMatrix metalloproteinase 9 (MMP-9) plays a critical role in digesting the extracellular matrix and has a vital function in tumor metastasis and invasion; this protease activity is significantly increased in non-small cell lung cancers. The sodium hydrogen exchanger isoform 1 (NHE1) functions as a focal point for signal coordination and cytoskeletal reorganization. NHE1 is thought to play a central role in establishing signaling components at the leading edge of a migrating cell.
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