Publications by authors named "Danielle R Santos"
The Prolonged Activation of the p65 Subunit of the NF-Kappa-B Nuclear Factor Sustains the Persistent Effect of Advanced Glycation End Products on Inflammatory Sensitization in Macrophages.
Int J Mol Sci
February 2024
Article Synopsis
- * Macrophages pre-treated with AGE-albumin released higher levels of inflammatory cytokines (TNF, IL-6, IL-1beta) compared to those treated with control albumin, with notable increases persisting for up to 24 hours.
- * The p65 subunit of nuclear factor kappa B (NFKB) shows prolonged activation in AGE-treated macrophages, suggesting that targeting this pathway could help manage inflammation-related complications.
Increased plasma lipids in triple-negative breast cancer and impairment in HDL functionality in advanced stages of tumors.
Sci Rep
June 2023
The association between plasma lipids and breast cancer (BC) has been extensively explored although results are still conflicting especially regarding the relationship with high-density lipoprotein cholesterol (HDLc) levels. HDL mediates cholesterol and oxysterol removal from cells limiting sterols necessary for tumor growth, inflammation, and metastasis and this may not be reflected by measuring HDLc. We addressed recently diagnosed, treatment-naïve BC women (n = 163), classified according to molecular types of tumors and clinical stages of the disease, in comparison to control women (CTR; n = 150) regarding plasma lipids and lipoproteins, HDL functionality and composition in lipids, oxysterols, and apo A-I.
View Article and Find Full Text PDFPurpose: This study evaluated the involvement of endogenous kallikrein-kinin system and the bradykinin (BK) B and B receptors on LPS- induced fever and the POA cells involved in this response.
Material And Methods: Male Wistar rats received either i.v.
Tityus serrulatus venom (Tsv) was intraperitoneally (ip) injected at doses of 75, 150 and 300mug/kg and IL-1beta (2.0 microg/kg) was given intravenously (iv) to male Wistar rats. Rectal temperature was measured by radiotelemetry.
View Article and Find Full Text PDF1 This study examines the involvement of kinins in neutrophil migration into rat subcutaneous air pouches triggered by lipopolysaccharide (LPS), as well as the putative roles played by kinin B(1) and B(2) receptors, tumour necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and selectins in this response. 2 LPS (5 ng to 10 micro g cavity(-1)) injected into the 6-day-old pouch induced a dose- and time-dependent neutrophil migration which peaked between 4 and 6 h, and was maximal following the dose of 100 ng cavity(-1) (saline: 0.46+/-0.
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