Publications by authors named "Danielle Ohana"
Article Synopsis
- * The majority of the patients had severe COVID-19, with 90% showing abnormal ASL perfusion, particularly hypoperfusion in the temporal poles and frontal lobes, even if traditional MRI scans appeared normal.
- * The findings highlight that over 80% of these patients exhibited significant brain perfusion deficits, suggesting that neurological complications in COVID-19 can occur independently of visible lesions on standard MRI scans.
The therapeutic action of drugs is predicated on their physical engagement with cellular targets. Here we describe a broadly applicable method using bioluminescence resonance energy transfer (BRET) to reveal the binding characteristics of a drug with selected targets within intact cells. Cell-permeable fluorescent tracers are used in a competitive binding format to quantify drug engagement with the target proteins fused to Nanoluc luciferase.
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