Peripheral artery disease (PAD) worsens outcomes in patients undergoing percutaneous coronary intervention (PCI), especially in those categorized as high bleeding risk (HBR).
In a study of 16,750 patients, those with PAD in the HBR group experienced higher rates of major adverse cardiac events (MACE) at one year compared to non-PAD patients, while bleeding risks were also higher but not statistically significant.
Once adjusting for other cardiovascular risks and comorbidities, the negative impact of PAD on adverse outcomes after PCI diminished significantly.