Ophthalmic effects of dexmedetomidine, methadone and dexmedetomidine-methadone in healthy cats and their reversal with atipamezole.

Objectives: The aims of this study were to evaluate and compare the effects that dexmedetomidine and methadone, either alone or in combination, have on the ocular variables of healthy adult cats when administered intramuscularly, as well as their reversal with atipamezole.

Methods: A randomized crossover blinded study of 10 healthy cats was used to assess the effect of 0.2 mg/kg methadone (MET), 7.