Publications by authors named "Danielle M Ware"
Article Synopsis
- AAA proteins are involved in remodeling other proteins, influencing various biological processes through the coupling of substrate binding and conformational changes driven by nucleotide binding and hydrolysis.
- In the study focused on the AAA protein Hsp104, engaging with polypeptides at a specific region induces a conformational change that drives ATP hydrolysis in another domain of the protein.
- This interdomain communication is essential for function and can be disrupted by mutations or antibodies that block the middle region, underscoring its importance in the protein's signaling mechanism.
