Publications by authors named "Danielle M Press"
Background: The electronic medical record (EMR) of a large, tertiary referral center was examined to study the prevalence of undiagnosed and unrecognized primary hyperparathyroidism (PHPT).
Methods: The EMR was queried for outpatient serum calcium >10.5 mg/dL over a 2-year period.
The mouse mu-opioid receptor gene, Oprm1, currently contains 18 recognized alternatively spliced exons [Doyle, G.A., Sheng, X.
View Article and Find Full Text PDFThe mouse mu-opioid receptor gene, Oprm1, is recognized currently to contain 17 alternatively spliced exons that generate 24 splice variants encoding at least 11 morphine-binding isoforms of the receptor. Here, we identify three new MOR splice variants that contain a previously undescribed exon, exon 18, and provide evidence that they are expressed in two mouse strains. The transcripts containing the newly identified exon 18 encode two new putative mu-opioid receptor isoforms, MOR-1V and MOR-1W.
View Article and Find Full Text PDFArticle Synopsis
- A study confirmed that a specific region on mouse Chromosome 1 is linked to seizure susceptibility differences between seizure-resistant C57BL/6 and seizure-sensitive DBA/2 mice, narrowing down the area to a 4.1-Mb critical interval.
- Within this interval, researchers identified 12 genes with variations (SNPs) that could affect protein function, focusing particularly on the Kcnj10 gene as a significant factor influencing seizure susceptibility.
- The findings suggest that the B6 variant of Kcnj10 is associated with higher seizure thresholds, indicating its potential role in understanding seizure genetics and physiology in mice.