Publications by authors named "Danielle K Almstead"
Article Synopsis
- Immunocytokines, like KD033, combine an antitumor antibody with an immune-activating cytokine to target and activate the immune response in cancer's immunosuppressive environment.
- A surrogate version of KD033 (srKD033) demonstrated strong antitumor effects and durable immunity in mouse models, particularly in colon tumors, by promoting the expansion of cytotoxic immune cells.
- The srKD033 treatment was well-tolerated and showed significant effectiveness against tumors resistant to standard therapies, highlighting its potential as a promising cancer treatment option.
A generic activation mode for asymmetric LUMO-lowering catalysis has been developed using the long-established principles of oxy-allyl cation chemistry. Here, the enantioselective conversion of racemic α-tosyloxy ketones to optically enriched α-indolic carbonyls has been accomplished using a new amino alcohol catalyst in the presence of electron-rich indole nucleophiles. Kinetic studies reveal that the rate-determining step in this S(N)1 pathway is the catalyst-mediated α-tosyloxy ketone deprotonation step to form an enantiodiscriminant oxy-allyl cation prior to the stereodefining nucleophilic addition event.
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