Publications by authors named "Danielle Henley"
Polycomb group (PcG) proteins play important roles in hematopoietic stem cell (HSC) self-renewal. Mel18 and Bmi1 are homologs of the PCGF subunit within the Polycomb repressive complex 1 (PRC1). Bmi1 (PCGF4) enhances HSC self-renewal and promotes terminal differentiation.
View Article and Find Full Text PDFBmi1 Regulates Wnt Signaling in Hematopoietic Stem and Progenitor Cells.
Stem Cell Rev Rep
December 2021
Polycomb group protein Bmi1 is essential for hematopoietic stem cell (HSC) self-renewal and terminal differentiation. However, its target genes in hematopoietic stem and progenitor cells are largely unknown. We performed gene expression profiling assays and found that genes of the Wnt signaling pathway are significantly elevated in Bmi1 null hematopoietic stem and progenitor cells (HSPCs).
View Article and Find Full Text PDFAn amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFArticle Synopsis
- Clonal hematopoiesis of indeterminate potential (CHIP) is a condition that gets more common as people age and can lead to blood cancers.
- Mutations in the TP53 gene can give an advantage to blood stem cells, helping them grow more after stress like radiation.
- The study found that the mutant p53 protein helps another protein called EZH2 stick to certain genes, boosting their activity and leading to the expansion of these blood stem cells, which could be a target for new treatments.