Publications by authors named "Danielle Feio da Costa"
Gastric cancer (GC) is the fifth most common type of tumor and the third leading cause of cancer death worldwide. The evolution of gastric carcinogenesis is still poorly understood and, for this reason, preclinical research protocols were established that included the development of gastric cancer cell lines and the establishment of models of gastric carcinogenesis in non-human primates such as Sapajus apella. A comprehensive literature search was performed in relevant databases such as PubMed, ResearchGate, and Google Scholar to identify studies related to the topic.
View Article and Find Full Text PDFInfluence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.
Marianne Rodrigues Fernandes Juliana Carla Gomes Rodrigues Elizabeth Ayres Fragoso Dobbin Lucas Favacho Pastana Danielle Feio da Costa Artur Luiz da Costa Silva
Cancer Chemother Pharmacol
November 2021
Article Synopsis
- Fluoropyrimidines are commonly used cancer drugs but have significant toxicity, and this study examined genetic variations in patients treated with these drugs in the Brazilian Amazon.
- The research involved 216 patients with gastrointestinal cancers, analyzing 33 gene polymorphisms and using advanced genotyping technology to assess ancestry and potential toxicity risks.
- Four specific genetic polymorphisms (in the ABCC4, FPGS, SLC29A1, and MTHFR genes) were identified as significant predictors of toxicity, highlighting the importance of personalized medicine in this unique population.