Publications by authors named "Danielle De Bourcier"
Int J Mol Sci
September 2019
Article Synopsis
- WWP2 is an E3 ubiquitin ligase that regulates TGFβ signaling through different isoforms, affecting tumor suppressor and progression pathways.
- The WW4 domain of WWP2 promotes degradation of Smad7, aiding in cancer-related processes like epithelial-mesenchymal transition, suggesting its potential as a therapeutic target.
- NMR spectroscopy reveals WWP2's structure and binding affinities, showing that specific isoforms can enhance or inhibit TGFβ signaling, highlighting the complex regulation of this pathway in cancer.
