Publications by authors named "Danielle Crowell"
Article Synopsis
- Recent studies show that while certain chemicals increase hemangiosarcoma (HSA) incidence in mice, the implications for humans remain unclear.
- Canine HSAs provide a valuable model for understanding human HSAs, exhibiting distinct cellular phenotypes such as expressing endothelial cell (EC) markers more reliably than hematopoietic stem cell (HSC) markers.
- Key differences were noted: human HSAs showed consistent HSC marker expression indicating less differentiation compared to canine and mouse HSAs, while both human and canine HSAs displayed late-stage EC maturation markers absent in mice, highlighting species variability in HSA development and translating risk from animal studies to humans.
C-X-C chemokine receptor type 7 (CXCR7) is involved in cardiac and immune pathophysiology. We report the discovery of a novel 1,4-diazepine CXCR7 modulator, demonstrating for the first time the role of pharmacological CXCR7 intervention in cardiac repair. Structure-activity-relationship (SAR) studies demonstrated that a net reduction in lipophilicity (log D) and an incorporation of saturated ring systems yielded compounds with good CXCR7 potencies and improvements in oxidative metabolic stability in human-liver microsomes (HLM).
View Article and Find Full Text PDF