The Okur-Chung Neurodevelopmental Syndrome Mutation CK2 Leads to a Rewiring of Kinase Specificity.

Okur-Chung Neurodevelopmental Syndrome (OCNDS) is caused by heterozygous mutations to the gene, which encodes the alpha subunit of protein kinase CK2. The most frequently occurring mutation is lysine 198 to arginine (K198R). To investigate the impact of this mutation, we first generated a high-resolution phosphorylation motif of CK2, including the first characterization of specificity for tyrosine phosphorylation activity.

Teriflunomide Safety and Efficacy in Advanced Progressive Multiple Sclerosis.

Objectives: To explore the safety and efficacy profile of teriflunomide in progressive multiple sclerosis.

Methods: We conducted a single-center retrospective observational analysis of a progressive multiple sclerosis population, assessing safety and efficacy in patients treated at least one year with teriflunomide or glatiramer acetate. Sustained progression of expanded disability status scale and sustained worsening of timed 25-foot walk were compared using a Cox proportional hazards model.