Circulating Metabolites as Biomarkers of Disease in Patients with Mesial Temporal Lobe Epilepsy.

A major challenge in the clinical management of patients with mesial temporal lobe epilepsy (MTLE) is identifying those who do not respond to antiseizure medication (ASM), allowing for the timely pursuit of alternative treatments such as epilepsy surgery. Here, we investigated changes in plasma metabolites as biomarkers of disease in patients with MTLE. Furthermore, we used the metabolomics data to gain insights into the mechanisms underlying MTLE and response to ASM.

Multi-omic strategies applied to the study of pharmacoresistance in mesial temporal lobe epilepsy.

Mesial temporal lobe epilepsy (MTLE) is the most common type of focal epilepsy in adults, and hippocampal sclerosis (HS) is a frequent histopathological feature in patients with MTLE. Pharmacoresistance is present in at least one-third of patients with MTLE with HS (MTLE+HS). Several hypotheses have been proposed to explain the mechanisms of pharmacoresistance in epilepsy, including the effect of genetic and molecular factors.

Using the AHEC Scholars Program to Enhance Health Professions Learners' Self-Efficacy for Practice Transformation.

The Indiana Area Health Education Centers Scholars program is a 2-year leadership program designed to supplement health professions students' academic training and enhance practice readiness around 6 core topic areas including practice transformation. The study was a retrospective cohort study assessing learners' reported level of self-efficacy on a set of 6 competencies around practice transformation and quality improvement. A total of 68 students graduating in the first cohort responded to the competency questions.

Multi-omics in mesial temporal lobe epilepsy with hippocampal sclerosis: Clues into the underlying mechanisms leading to disease.

Mesial temporal lobe epilepsy (MTLE) is one of the most common types of focal epilepsy in the adult population. MTLE is frequently associated with a specific histopathological lesion in the medial temporal structures, namely hippocampal sclerosis (HS). A significant proportion of patients with MTLE+HS have severe epilepsy, which is often resistant to clinical treatment.

Prolonged growth of Candida albicans reveals co-isolated bacteria from single yeast colonies.

Bacterial species are associated with Candida albicans in at least 25% of patients with bloodstream infection (Candidemia). These polymicrobial infections are usually caused by coagulase-negative staphylococci, most commonly Staphylococcus epidermidis and are associated with significantly worse clinical outcomes as compared to monomicrobial infections. Here we show that bacteria are present in C.

Genome Sequence of a Staphylococcus epidermidis Strain (GTH12) Associated with Candida albicans SC5314 Cultured under Hypoxia at 37°C in Glycerol for 12 Weeks.

Polymicrobial infections with mixed-species biofilms are important health problems because of increased antimicrobial resistance and worse patient outcomes than with monomicrobial infections. Here, we present the whole-genome sequence of strain GTH12, which was cocultured with the yeast SC5314 (generating strain SC5314 GTH12), thus providing genomic information on polymicrobial infections.

Evidence for Mitochondrial Genome Methylation in the Yeast : A Potential Novel Epigenetic Mechanism Affecting Adaptation and Pathogenicity?

The commensal yeast is an opportunistic pathogen. In order to successfully colonize or infect the human body, the fungus must adapt to the host's environmental conditions, such as low oxygen tension (hypoxia), temperature (37°C), and the different carbon sources available. Previous studies demonstrated the adaptive importance of genetic variability for its pathogenicity, although the contributions of epigenetic and the influence of environmental factors are not fully understood.

Whole-Genome Sequences and Annotation of the Opportunistic Pathogen Strain SC5314 Grown under Two Different Environmental Conditions.

The genetic variability of the opportunistic pathogen is an important adaptive mechanism. Here, we present the whole-genome sequences of the SC5314 strain under two different growth conditions, providing useful information for comparative genomic studies and further intraspecific analysis.