Intra-articular bone marrow concentrate injection protocol: short-term efficacy in osteoarthritis.

Aim: Evaluate intra-articular injection of bone marrow concentrate (BMC), followed by platelet-rich plasma (PRP) injection at 8 weeks follow-up in moderate/severe osteoarthritis.

Design: Single center, retrospective Case Series (n = 125).

Methods: Bone marrow was aspirated/concentrated using a standardized technique.

Stem cell therapies for treatment of cartilage and bone disorders: osteoarthritis, avascular necrosis, and non-union fractures.

The general ease of availability and strong fundamental science of autologous mesenchymal stem cells has prompted increasing application of such biologic therapies to address inherent orthopedic challenges of limited vascularity and ability to self-repair. This article provides a concise review of emerging mesenchymal stem cell applications for bone-related pathologies including cartilage, avascular necrosis, and fractures.

Autologous bone marrow concentrate: review and application of a novel intra-articular orthobiologic for cartilage disease.

Younger adults, aged < 65 years, increasingly present to their physicians with advanced cartilage disease or post-traumatic osteoarthritis. A number of treatments exist for lessening patient pain and improving patient function. However, many patients are becoming aware of the potential of regenerative therapies and are now seeking solutions to the impaired biology underlying their conditions rather than addressing only their symptoms.

Management of Dupuytren contracture with ultrasound-guided lidocaine injection and needle aponeurotomy coupled with osteopathic manipulative treatment.

Dupuytren contracture is a debilitating disease that characteristically presents as a firm nodularity on the palmar surface of the hand with coalescing cords of soft tissue on the webs and digits. With few nonsurgical modalities providing clinical benefits, open surgical procedures are the standard of care for patients with this condition. However, recent studies have associated surgical intervention with many complications, necessitating further exploration of nonsurgical treatment options.