Addressing Prompt Dependency in the Treatment of Challenging Behavior Maintained by Access to Tangible Items.

Prompt dependency is a common concern for individuals with developmental disabilities, particularly autism spectrum disorder. Previous research has shown that different interventions can be used to decrease prompt dependency. The purpose of the present study was to evaluate the efficacy of various treatments to decrease prompt dependency during functional communication training in the treatment of challenging behavior maintained by access to tangible items in a 16-year-old female diagnosed with autism spectrum disorder.

Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung's disease.

Purpose: Interstitial cells of Cajal (ICCs) are pacemaker cells involved in facilitating neurotransmission and the generation of slow electrical waves necessary for colonic peristalsis. Their distribution has been found to be abnormal in the aganglionic and ganglionic colon in Hirschsprung's disease (HSCR) using c-kit-labelling. Anoctamin-1 (ANO1) is a Ca(2+)-activated Cl(-) channel thought to be specifically expressed on ICCs.