Publications by authors named "Daniella Ugay"
Stress granules and P-bodies are ribonucleoprotein (RNP) granules that accumulate during the stress response due to the condensation of untranslating mRNPs. Stress granules form in part by intermolecular RNA-RNA interactions and can be limited by components of the RNA chaperone network, which inhibits RNA-driven aggregation. Herein, we demonstrate that the DEAD-box helicase DDX6, a P-body component, can also limit the formation of stress granules, independent of the formation of P-bodies.
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- The glucocorticoid receptor (GR) is a protein that helps regulate gene expression by binding to DNA and may also interact with RNA, although its exact role in this interaction is unclear.
- Researchers created a mutant version of GR that has a lower ability to bind RNA and treated it with a drug called dexamethasone to study changes in gene activity.
- Findings indicate that GR-RNA interactions can repress certain genes' activity, suggesting that RNA may compete with DNA for GR binding, influencing gene expression in ways related to both chromatin structure and RNA presence.
Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood.
Dement Neurocogn Disord
March 2020
Alzheimer's disease (AD) is pathologically characterized by a long progressive phase of neuronal changes, including accumulation of extracellular amyloid-β (Aβ) and intracellular neurofibrillary tangles, before the onset of observable symptoms. Many efforts have been made to develop a blood-based diagnostic method for AD by incorporating Aβ and tau as plasma biomarkers. As blood tests have the advantages of being highly accessible and low cost, clinical implementation of AD blood tests would provide preventative screening to presymptomatic individuals, facilitating early identification of AD patients and, thus, treatment development in clinical research.
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