Publications by authors named "Daniella Rego"
Patients with active acromegaly have a higher percentage of lean body mass, a lower percentage of fat body mass, and an increase in their extracellular water compartment compared to healthy individuals. However, muscle function appears to be compromised in patients with acromegaly, with some experiencing worsened physical performance and sarcopenia. Myokine alterations, insulin resistance, dysregulation of protein metabolism, muscle oxidative stress, neuromuscular junction impairment, and increased ectopic intramuscular fat deposits may play roles in muscle dysfunction in patients with acromegaly.
View Article and Find Full Text PDFBackground: Parathyroid carcinoma accounts for <1% of cases of primary hyperparathyroidism (PHPT). This rare condition may present with severe hypercalcemia and bone complications such as osteoclastomas and pathologic fractures. Here, we present a rare condition of panhypopituitarism resulting from an osteoclastoma in the sphenoid bone that invaded the pituitary fossa due to parathyroid carcinoma.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluated body composition and hormonal control in 28 patients with acromegaly, comparing the effectiveness of Bioelectrical Impedance Analysis (BIA) with Dual X-ray Absorptiometry (DXA).
- Results showed that patients with controlled acromegaly had lower levels of growth hormone and IGF-1 but similar body composition measurements for fat and muscle mass when compared with those having active disease.
- The findings indicate a strong correlation between BIA and DXA in assessing body composition, and highlight that adequately controlled patients had better metabolic outcomes, including lower fasting glucose and fewer instances of type 2 diabetes and high blood pressure.