Publications by authors named "Daniella R B da S Novi"
Metformin (MET) is prescribed for the treatment of type 2 diabetes mellitus and gestational diabetes. Although MET crosses the placenta, it is considered safe throughout gestation. However, it has been shown in humans that maternal exposure to MET increases sex hormone binding globulin levels in newborns, and in rats it decreases the testosterone concentration at gestational day (GD) 16.
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- The study focuses on the impact of the antidepressant fluoxetine on the aorta's response to stress in adult male offspring, as mothers took the drug during pregnancy and lactation.
- Researchers found that acute stress impaired the aorta's contraction in control rats, but fluoxetine-exposed rats did not show this change, indicating altered stress responses due to maternal fluoxetine treatment.
- Findings suggest that maternal fluoxetine use can decrease nitric oxide system activation and impair aortic adaptation to stress in adult offspring, indicating potential long-term effects of prenatal exposure.