Publications by authors named "Daniella R B S Novi"
Paracetamol (PAR) is the most common over-the-counter drug recommended by physicians for treatment of pain and fever during gestation. This drug is not teratogenic, being considered safe for fetus; however, PAR crosses the blood-placental barrier. Considering that, the present study aimed to evaluate the vascular and metabolic safety of PAR exposure during intrauterine and neonatal development in adult male and female-exposed offspring.
View Article and Find Full Text PDFThe aim was to evaluate if maternal treatment with metformin (MET) during pregnancy and lactation could be safe for metabolic and cardiovascular parameters of adult male and female offspring. Wistar female rats were treated with MET (293 mg/kg/d) or tap water, by gavage during gestation (METG or CTRG) or gestation and lactation (METGL or CTRGL). At 75 days of life, male and female MET offspring presented similar blood pressure when compared with their CTR.
View Article and Find Full Text PDFThe biguanide metformin (MET) has been used during pregnancy for treatment of polycystic ovary syndrome and gestational diabetes. MET crosses the placenta and maternal treatment can expose the progeny to this drug during important phases of body development. Direct vascular protective effects have been described with the treatment of metformin.
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- The study focuses on the impact of the antidepressant fluoxetine on the aorta's response to stress in adult male offspring, as mothers took the drug during pregnancy and lactation.
- Researchers found that acute stress impaired the aorta's contraction in control rats, but fluoxetine-exposed rats did not show this change, indicating altered stress responses due to maternal fluoxetine treatment.
- Findings suggest that maternal fluoxetine use can decrease nitric oxide system activation and impair aortic adaptation to stress in adult offspring, indicating potential long-term effects of prenatal exposure.
Metformin has been used for the treatment of some metabolic diseases during gestation and the beneficial effects of metformin to the vascular system have been described in diabetic and obese animal models. Nevertheless, the long-term consequences to the vascular system of offsprings maternally exposed to metformin have not yet been characterized. Therefore, we want to test the hypothesis that gestational and lactational exposure to metformin would be safe for the vascular reactivity of male adult offsprings.
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