Publications by authors named "Daniele Travaglia"

Article Synopsis
  • The study explores the link between estrogen replacement therapy and ovarian cancer risk, particularly focusing on high-grade serous ovarian cancer (HGSOC).
  • It finds that Estrogen Receptor Alpha (ERα) is crucial for the growth of HGSOC cells, while increased estrogen levels also promote growth in ERα-negative cancers.
  • Additionally, the research highlights that estrogen influences the tumor microenvironment, suggesting that both direct and indirect mechanisms contribute to estrogen-induced tumor growth in HGSOC.
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Aims: Male sex is a risk factor for medulloblastoma (MB), and is also a negative predictor for clinical outcome. The aim of this study was to assess sex differences in tumour biological features and hormone receptor profiles in a cohort of MB patients.

Methods And Results: Sixty-four MBs and five normal cerebella were included in the study.

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Article Synopsis
  • The study investigates the role of cytoplasmic estrogen receptor β2 (cERβ2) in serous ovarian cancer, focusing on its impact on cell survival and apoptosis.
  • Using immunohistochemistry and immunofluorescence on 56 advanced cancer cases, researchers found that cERβ2 expression was associated with a lower rate of apoptosis, though it did not influence cell proliferation.
  • The study concludes that cERβ2 interacts with proteins involved in the apoptosis process within mitochondria, acting as a protective factor against apoptosis and highlighting its potential as a negative prognostic marker for serous ovarian cancer.
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Background: The male-to-female sex ratio for medulloblastoma (MB) is approximately 1.5∶1, female gender being also a favorable prognostic factor. This study aimed at evaluating the impact of gender on MB tumorigenesis.

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Objective: In the present study we have examined the pattern of expression of the full length estrogen receptor β (ERβ1) and two ERβ splice variant isoforms (ERβ2, ERβ5) in well-characterized advanced serous ovarian cancers.

Methods: Immunohistochemistry was performed with ERβ1, ERβ2, and ERβ5 antibodies and results were correlated with pathological and clinical follow-up data. Expression of ERβ isoforms in a panel of ovarian cancer cell lines and human tumor xenografts was also assessed.

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The prognostic relevance of estrogen (ER) and progesterone receptor (PR) expression in endometrioid endometrial cancer is still controversially discussed. The present study has focused on the evaluation of the prognostic value of ERα, ERβ1, ERβ2, and PR in this histotype. Specifically, we were interested in evaluating whether the relative level of ER subtype-specific expression (in terms of a ratio ERα/ERβ1 and ERα/ERβ2) would predict clinical outcome better than their absolute levels in patients with endometrioid endometrial cancer.

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Purpose: Hyaluronan (HA)-receptors (mainly CD44 and RHAMM) are overexpressed in a wide variety of cancers including ovarian tumors, and HA-bioconjugates have been developed to enhance selective entry of cytotoxic drugs into HA receptor-expressing cancerous cells. Here, we evaluated the potential application of a new HA-paclitaxel bioconjugate, ONCOFID-P, for intraperitoneal (IP) treatment of ovarian cancer.

Methods: In vitro cytotoxic effect of ONCOFID-P was first assessed on CD44(+) OVCAR-3 and SKOV-3 human ovarian cancer cell lines.

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This study was aimed at evaluating the potential application of benzophenanthridine alkaloids, sanguinarine and cheleritrine, in the therapy of melanoma cancer. In vitro antiproliferative activity of sanguinarine was higher than that of cheleritrine against the B16 melanoma 4A5 cells. Both agents were able to produce DNA breaks, and the DNA unwinding assay showed that they act as DNA intercalating agents.

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Objective: This study was designed to compare the effects of 17beta-estradiol (17beta-E2) and a phytoestrogen-containing soy extract on the immune system in an ovariectomized rat model of menopause. Specifically, T- and B-lymphocyte subsets, the balance of type 1 and 2 immune responses in the mesenteric lymph nodes, and serum levels of different classes of immunoglobulin were examined as study endpoints.

Design: Ovariectomized rats were treated with either the phytoestrogen-containing soy extract (50 or 100 mg/kg/day PO), 17beta-E2 (0.

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