Stratification of multiple sclerosis patients using unsupervised machine learning: a single-visit MRI-driven approach.

Objectives: To stratify patients with multiple sclerosis (pwMS) based on brain MRI-derived volumetric features using unsupervised machine learning.

Methods: The 3-T brain MRIs of relapsing-remitting pwMS including 3D-T1w and FLAIR-T2w sequences were retrospectively collected, along with Expanded Disability Status Scale (EDSS) scores and long-term (10 ± 2 years) clinical outcomes (EDSS, cognition, and progressive course). From the MRIs, volumes of demyelinating lesions and 116 atlas-defined gray matter regions were automatically segmented and expressed as z-scores referenced to external populations.

Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in Humans.

Chronic itch can severely affect quality of life. Patients report that their chronic itch can be exacerbated by exposure to warm conditions ("warmth hyperknesis"). The aim of this mechanistic study was to investigate the effect of mild heating of the skin in humans on various experimental models of itch.

Time-Domain and Monostatic-like Frequency-Domain Methods for Bistatic SAR Simulation.

In recent years, an increasing interest has been devoted to bistatic SAR configurations, which can be effectively used to improve system performance and/or to increase the amount of physical information retrievable from the observed scene. Within this context, the availability of simulation tools is of paramount importance, for both mission planning and processing algorithm verification and testing. In this paper, a time domain simulator useful to obtain the point-spread function and the raw signal for the generic bistatic SAR configuration is presented.

Software Tool for Soil Surface Parameters Retrieval from Fully Polarimetric Remotely Sensed SAR Data.

The retrieval of soil surface parameters, in particular soil moisture and roughness, based on Synthetic Aperture Radar (SAR) data, has been the subject of a large number of studies, of which results are available in the scientific literature. However, although refined methods based on theoretical/analytical scattering models have been proposed and successfully applied in experimental studies, at the operative level very simple, empirical models with a number of adjustable parameters are usually employed. One of the reasons for this situation is that retrieval methods based on analytical scattering models are not easy to implement and to be employed by non-expert users.

Integration of Sentinel-1 and Sentinel-2 Data for Land Cover Mapping Using W-Net.

In this paper, we present a new approach to the fusion of Sentinel 1 (S1) and Sentinel 2 (S2) data for land cover mapping. The proposed solution aims at improving methods based on Sentinel 2 data, that are unusable in case of cloud cover. This goal is achieved by using S1 data to generate S2-like segmentation maps to be used to integrate S2 acquisitions forbidden by cloud cover.

Perturbation Theory for Scattering from Multilayers with Randomly Rough Fractal Interfaces: Remote Sensing Applications.

A general, approximate perturbation method, able to provide closed-form expressions of scattering from a layered structure with an arbitrary number of rough interfaces, has been recently developed. Such a method provides a unique tool for the characterization of radar response patterns of natural rough multilayers. In order to show that, here, for the first time in a journal paper, we describe the application of the developed perturbation theory to fractal interfaces; we then employ the perturbative method solution to analyze the scattering from real-world layered structures of practical interest in remote sensing applications.

Integrated Toolset for WSN Application Planning, Development, Commissioning and Maintenance: The WSN-DPCM ARTEMIS-JU Project.

In this article we present the main results obtained in the ARTEMIS-JU WSN-DPCM project between October 2011 and September 2015. The first objective of the project was the development of an integrated toolset for Wireless sensor networks (WSN) application planning, development, commissioning and maintenance, which aims to support application domain experts, with limited WSN expertise, to efficiently develop WSN applications from planning to lifetime maintenance. The toolset is made of three main tools: one for planning, one for application development and simulation (which can include hardware nodes), and one for network commissioning and lifetime maintenance.