Publications by authors named "Daniele Melo Sardinha"

Article Synopsis
  • - Leprosy, a chronic infectious disease with significant disabling effects, presents a major public health challenge in Brazil, which has the second-highest number of cases globally, following India.
  • - A systematic review and meta-analysis of studies from the last 20 years was conducted to analyze the prevalence of paucibacillary leprosy in Brazil, utilizing various databases and following strict methodological guidelines.
  • - The findings from 48 studies indicated a prevalence rate of 50.5% for paucibacillary cases in Brazil, with regional variations, showing the highest frequency in the Midwest and the lowest in the South, and no significant publication bias detected.
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The common cold is the primary cause of illness in the community, with over 200 viral strains identified, and rhinovirus infections being the most prevalent. Coronavirus Disease 19 (COVID-19) is also a significant cause of severe illness. The burden of acute respiratory infections has a significant impact on the economy, resulting in absenteeism from work and school.

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Background: Leprosy is a chronic and disabling infectious disease caused by . It has a wide clinical spectrum and is operationally classified into paucibacillary (PB) and multibacillary (MB) cases. There is evidence that the gene can be used in Polymerase Chain Reaction (PCR) for complementary detection with high sensitivity and specificity.

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Article Synopsis
  • This study focuses on the opportunistic pathogen's antimicrobial resistance (AMR) and virulence, particularly the type III secretion system (T3SS) that contributes to its pathogenicity and treatment challenges.
  • Researchers conducted a systematic review and meta-analysis of studies from 2011 to 2023 to evaluate the prevalence of high-risk clones (HRCs) in Brazilian isolates using multilocus sequence typing (MLST).
  • Findings revealed that almost half of the MLST-typed isolates were HRCs, with significant regional differences in prevalence, emphasizing the importance of understanding these clones in relation to AMR issues in Brazil.
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Chronic HIV-1 infection can cause neurological illness, also known as HIV-associated neurocognitive disorders (HAND). The elevated level of pro-inflammatory cytokines and chemokines, such as C-C Chemokine Ligand 5 (CCL5/RANTES), is one of the ways of causing HIV-1-mediated neuroinflammation. C-C Chemokine Receptor 5 (CCR5) is the main coreceptor for viral entry into host cells and for mediating induction of CCL5/RANTES.

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Introduction: COVID-19 in Brazil has already caused, and it still causes, several impacts on health, economy, and education. The risk factors for death involved those with cardiovascular diseases (CVD), which were prioritized for the vaccination of COVID-19.

Objective: To investigate the clinical characteristics and outcomes between vaccinated and unvaccinated patients with cardiovascular diseases hospitalized for COVID-19 in Brazil in the year 2022.

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The northern region of Brazil is already vulnerable to other infectious diseases and it was no different in COVID-19. However, cardiovascular diseases still lead the causes of death. Thus, the objective of this study is to identify the clinical predictors and outcome of severe COVID-19 in hospitalized patients with and without CVD in this region of the Amazon.

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The city of Ananindeua, State of Pará, Brazil, is a hyperendemic area for tuberculosis (TB). The present study describes the population characteristics and epidemiological indicators of TB cases from Ananindeua, from 2018 to 2020. The TB cases were screened from the Municipal Health Department of Ananindeua database, and the secondary data were obtained from the Brazilian Notifiable Diseases Information System (SINAN).

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The Brazilian Northern region registered a high incidence of COVID-19 cases, particularly in the state of Pará. The present study investigated the risk factors associated with the severity of COVID-19 in a Brazilian Amazon region of 100,819 cases. An epidemiological, cross-sectional, analytical and demographic study, analyzing data on confirmed cases for COVID-19 available at the Brazilian Ministry of Health's surveillance platform, was conducted.

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Malaria is an acute febrile infectious disease that represents an important public health problem in the Brazilian amazon region. The present study described the socio-epidemiological and spatial characteristics of malaria in a population from the Tapajós mining areas, Pará, Brazilian Amazon. A cross-sectional study, including individuals from Itaituba city, an area under mining activity influence, was conducted.

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appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by in cancer patients treated at an oncology referral center in the state of Pará, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by 72 h after hospital admission.

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Acute renal failure (ARF) represents 17% of the complications of cardiac catheterization (CC), with a high death rate and longer hospitalization time. The objective of this review is to describe the most cited risk factors for acute kidney failure in the literature. It is a descriptive and exploratory Integrative Literature Review (ILR) with a qualitative approach, using articles published in the Latin American and Caribbean Health Sciences Literature (LILACS) and PubMed databases between the years of 2009 and 2019 in English, Portuguese, and Spanish, including original articles, reviews, and case studies.

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