Increased IGF-I : IGFBP-3 ratio in patients with hepatocellular carcinoma.

Background: The development of hepatocellular carcinoma in liver cirrhosis is associated with altered synthesis and secretion of several growth factors.

Aim: The aim of this prospective study was to investigate the potential implication of IGF-I and its major binding protein (IGFBP-3) in the development of hepatocellular carcinoma.

Patients And Methods: IGF-I and IGFBP-3 were measured in 150 healthy subjects, 40 patients with liver cirrhosis and 63 with liver cirrhosis and untreated hepatocellular carcinoma.