Publications by authors named "Daniele Leao Ignacio"
Estrogen deficiency causes metabolic disorders in humans and rodents, including in part due to changes in energy expenditure. We have shown previously that skeletal muscle mitochondrial function is compromised in ovariectomized (Ovx) rats. Since physical exercise is a powerful strategy to improve skeletal muscle mitochondrial content and function, we hypothesize that exercise training would counteract the deficiency-induced skeletal muscle mitochondrial dysfunction in Ovx rats.
View Article and Find Full Text PDFGrowth hormone (GH) regulates whole body metabolism, and physical exercise is the most potent stimulus to induce its secretion in humans. The mechanisms underlying GH secretion after exercise remain to be defined. The aim of this study was to elucidate the role of estrogen and pituitary type 1 deiodinase (D1) activation on exercise-induced GH secretion.
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- Anabolic-androgenic steroid abuse is on the rise, with doses significantly higher than therapeutic levels (10- to 100-fold), leading to various side effects, particularly on glucose metabolism during fasting.
- This study focused on the effects of high doses of nandrolone decanoate (DECA) on glucose regulation in male Wistar rats, comparing low therapeutic doses to high supraphysiological doses over an 8-week period.
- Results showed that high doses of DECA led to increased insulin levels but reduced glucose uptake in skeletal muscle, decreased fasting serum glucose, and impaired gluconeogenesis, indicating major disruptions in glucose metabolism.
The hypothalamic-pituitary-thyroid axis is affected by acute exercise, but the mechanisms underlying thyroid function changes after exercise remain to be defined. The aim of this study was to elucidate the effects of a session of acute exercise on the treadmill at 75% of maximum oxygen consumption on thyroid function of rats. Male Wistar rats were divided into five groups: control (without exercise), and killed immediately after (0 min) or 30, 60, and 120 min after the end of the exercise session.
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