Targeting a Multidrug-Resistant Pathogen: First Generation Antagonists of 's BC2L-C Lectin.

Multidrug-resistant pathogens such as have become a hazard in the context of healthcare-associated infections, especially for patients admitted with cystic fibrosis or immuno-compromising conditions. Like other opportunistic Gram-negative bacteria, this pathogen establishes virulence and biofilms through lectin-mediated adhesion. In particular, the BC2L-C is believed to cross-link human epithelial cells to during pulmonary infections.