Comparison of low and high initial tacrolimus dosing in primary heart transplant recipients: a prospective European multicenter study.

Background: The purpose of this prospective, randomized, open-label, phase II, multicenter study was to optimize the initial oral dose of tacrolimus.

Methods: A total of 113 patients were randomly assigned to initial low-dose (0.075 mg/kg/day, n=55) or high-dose (0.