The study presents a fully-implantable device designed to monitor metabolites in free-moving small animals, specifically mice, using a microfabricated sensing platform.
It includes various components like a coil for power and data transmission and two custom integrated circuits, showcasing detailed system design and fabrication methods.
Biocompatibility was ensured through an epoxy-enhanced polyurethane membrane, which was effective for 35 days in retaining enzyme activity and showed low inflammation levels after 30 days in vivo.