Publications by authors named "Daniela de Mattos Grosso"
Article Synopsis
- Oxidative stress is linked to cardiovascular diseases in haemodialysis patients, and alpha-tocopherol (an antioxidant) can reduce levels of oxidized low-density lipoprotein (oxLDL) in these individuals.
- A study with 19 stable haemodialysis patients showed that after 120 days of taking alpha-tocopherol, LDL(-) levels significantly dropped from 570.9 to 169.1 microg/mL, while plasma alpha-tocopherol levels increased from 7.9 to 14.2 microM.
- The supplementation also led to a reduction in total cholesterol and LDL-C levels, suggesting potential cardiovascular benefits for these patients.
Background: Oxidative modification of low-density lipoprotein (LDL) plays a key role in the pathogenesis of atherosclerosis. LDL(-) is present in blood plasma of healthy subjects and at higher concentrations in diseases with high cardiovascular risk, such as familial hypercholesterolemia or diabetes.
Methods: We developed and validated a sandwich ELISA for LDL(-) in human plasma using two monoclonal antibodies against LDL(-) that do not bind to native LDL, extensively copper-oxidized LDL or malondialdehyde-modified LDL.
Paracoccidioidomycosis (PCM), one of the most important systemic mycoses in Central and South America, is caused by the dimorphic fungus Paracoccidioides brasiliensis and has a high prevalence in Brazil. Glycoproteins of 43 and 70 kDa are the main antigenic compounds of P. brasiliensis and are recognized by Western blotting by 100 and 96% of PCM patient sera, respectively.
View Article and Find Full Text PDFParacoccidioidomycosis (PCM) is a systemic granulomatous mycosis whose agent is Paracoccidioides brasiliensis. In the culture supernatant, the fungus expresses glycoproteins of from 13 to 148 kDa. A cell surface glycoprotein of 43 kDa is the major antigenic component of P.
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