Gender-related differences in the clinical presentation and outcome of hypertrophic cardiomyopathy.

Objectives: The goal of this study was to assess gender-related differences in a multicenter population with hypertrophic cardiomyopathy (HCM).

Background: Little is known regarding the impact of gender on the heterogeneous clinical profile and clinical course of HCM.

Methods: We studied 969 consecutive HCM patients from Italy and the U.

Prevalence and clinical profile of troponin T mutations among patients with hypertrophic cardiomyopathy in tuscany.

The prevalence and clinical profile of cardiac troponin T gene mutations were evaluated in 150 consecutive patients with hypertrophic cardiomyopathy from the well-defined geographic region of Tuscany. Troponin T mutations had a low prevalence (3.3%; including a newly described Phe110Leu mutation) and were associated with heterogeneous clinical expression and outcome.

Maximum left ventricular thickness and risk of sudden death in patients with hypertrophic cardiomyopathy.

Objectives: We sought to assess the relationship between maximum left ventricular (LV) wall thickness and outcome in patients with hypertrophic cardiomyopathy (HCM).

Background: An association between maximum LV wall thickness and risk of sudden death was suggested in HCM. This finding requires further investigation, given the important implications for risk stratification and treatment.