Publications by authors named "Daniela Trimmel"
Bone-derived stroma cells contain a rare subpopulation, which exhibits enhanced stemness characteristics. Therefore, this particular cell type is often attributed the mesenchymal stem cell (MSC). Due to their high proliferation potential, multipotential differentiation capacity, and immunosuppressive properties, MSCs are now widely appreciated for cell therapeutic applications in a multitude of clinical aspects.
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- Researchers investigated genetic factors involved in cellular aging using various human cell models and gathered their findings into the GiSAO database.
- They discovered new candidate genes linked to cellular aging that were previously unassociated, along with new pathways that might influence the aging process.
- Functional experiments confirmed several of these candidate genes, and further testing in yeast demonstrated how deleting specific genes could either shorten or extend lifespan, revealing evolutionarily conserved mechanisms of aging.