Publications by authors named "Daniela Trevino-Almaguer"
Article Synopsis
- Cordycepin, an adenosine analog, differs from adenosine by lacking a hydroxyl group at the 3' position, which allows it to be transformed into cordycepin triphosphate in certain tissues.
- This study utilized chemoinformatics, bioinformatics, and molecular dynamics simulations to compare cordycepin and its derivatives with natural purine metabolites, hypothesizing that cordycepin triphosphate can bind to adenylate cyclase similarly to ATP.
- The findings suggest that cordycepin triphosphate may inhibit cAMP production by acting as a pseudo-ATP, potentially enhancing antitumor immunity and influencing the behavior of cells in the tumor microenvironment
Metabolic reprogramming in cancer is considered to be one of the most important hallmarks to drive proliferation, angiogenesis, and invasion. AMP-activated protein kinase activation is one of the established mechanisms for metformin's anti-cancer actions. However, it has been suggested that metformin may exert antitumoral effects by the modulation of other master regulators of cellular energy.
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