Publications by authors named "Daniela Trabattoni"

Background The detection of in-stent restenosis (ISR) with coronary CT angiography (CCTA) is challenging, but CT perfusion (CTP) has demonstrated improved diagnostic accuracy over CCTA in patients with stents. However, there are limited data on the performance of dynamic CTP, which allows noninvasive adjudication of regional myocardial blood flow. Purpose To compare the diagnostic performance of regadenoson-stress dynamic CTP with that of CCTA, using fractional flow reserve (FFR) and the index of microvascular resistance (IMR) as reference standards for epicardial coronary circulation and coronary microcirculation, respectively.

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Limited evidence exists concerning the prognostic impact of baseline left ventricular ejection fraction (LVEF) on outcomes among women undergoing transcatheter aortic valve implantation (TAVI), which we aimed to investigate in the present analysis. Patients from the Women's International Transcatheter Aortic Valve Implantation (WIN-TAVI) registry were categorized according to baseline LVEF into 3 groups: reduced (LVEF ≤40%), mildly reduced (LVEF between 41% and 49%), and preserved (LVEF ≥50%) LVEF. The primary (Valve Academic Research Consortium 2 [VARC-2]) efficacy point was defined as a composite of mortality, stroke, myocardial infarction, hospitalization for valve-related symptoms or heart failure, or valve-related dysfunction at 1 year.

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Article Synopsis
  • Current guidelines recommend keeping LDL-C levels below 55 mg/100 ml for patients with acute coronary syndromes (ACS), but many patients struggle to reach this target due to poor medication adherence.
  • A study analyzed 963 ACS patients, using the Morisky Medication Adherence Scale to categorize them into high adherence (HA) and low adherence (LA) groups, finding that 28.7% had low adherence.
  • The results showed that HA patients were significantly more likely to achieve the LDL-C target compared to LA patients, indicating that adherence to lipid-lowering therapy plays a crucial role in reaching cholesterol goals.
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Patent foramen ovale (PFO) is often diagnosed in patients with cryptogenic stroke, aged > 60-65 years, but few data report the outcomes of PFO closure in elderly patients. Consecutive patients undergoing PFO closure at a single institution between January 2006 and December 2011 were included. Baseline clinical features and cerebral imaging data were collected, and a RoPE score was calculated for each patient.

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Transcatheter closure of a patent foramen ovale (PFO) is performed in cryptogenic stroke and other conditions. Information is lacking for some devices. We aimed to evaluate the Figulla Flex II PFO Occluder (FFP) and Figulla Flex UNI Occluder (FFU) through a retrospective multi-center registry.

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Introduction: Cardiovascular diseases are the leading cause of death among women. Prevention programmes underscore the need to address women-specific risk factors. Additionally, mental well-being is a significant aspect to consider when grappling with cardiovascular disease in women, particularly depression, anxiety, distress, and personality traits.

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Article Synopsis
  • The study evaluates the long-term impact of IntraVascular UltraSound (IVUS) on outcomes for patients with Unprotected Left Main (ULM) coronary artery disease undergoing Percutaneous Coronary Intervention (PCI).
  • Conducted across 13 European centers from 2002 to 2015, the research involved 627 patients, comparing those who received IVUS guidance to those who had traditional angiography.
  • Results showed that patients in the IVUS group experienced significantly fewer major adverse cardiovascular events (MACEs), all-cause death, and the need for further revascularization, suggesting that IVUS-guided PCI improves long-term patient outcomes.
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Background: In patients with acute coronary syndromes (ACS), current guidelines recommend a low-density lipoprotein cholesterol (LDL-C) level < 1.4 mmol/L (<55 mg/dL).

Methods: The JET-LDL is a multicenter, observational, prospective registry created to investigate levels of LDL-C in consecutive patients with ACS undergoing PCI at 35 Italian hospitals, and to report their lipid lowering therapies (LLT).

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Article Synopsis
  • Percutaneous closure of a patent foramen ovale (PFO) is a common procedure aimed at preventing recurrent strokes and treating related syndromes in specific patients.
  • While disc-based devices have been widely used for the past two decades, new suture-based devices are emerging as a promising option, although their long-term efficacy is not fully established.
  • The review covers current evidence on suture-based closure devices, including their characteristics, evaluation methods, patient selection guidelines, procedural steps, potential complications, and future advancements in the field.
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Background: The risks of prefrail and frail women undergoing transcatheter aortic valve replacement (TAVR) have not been fully examined. The aim of the analysis was to assess the prognostic impact of prefrailty and frailty in women undergoing TAVR.

Methods: Women at intermediate or high surgical risk with severe aortic stenosis undergoing TAVR from the prospective multicentre WIN-TAVI (Women's International Transcatheter Aortic Valve Implantation) registry were stratified based on the number of Fried frailty criteria (weight loss, exhaustion, low physical activity, slow gait, weakness) met: nonfrail (no criteria), prefrail (1 or 2 criteria), or frail (3 or more criteria).

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Background: ADP-induced platelet activation leads to cell surface expression of several proteins, including TF (tissue factor). The role of ADP receptors in platelet TF modulation is still unknown. We aimed to assess the (1) involvement of P2Y and P2Y receptors in ADP-induced TF exposure; (2) modulation of TF-platelets in anti-P2Y-treated patients with coronary artery disease.

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Background: Takotsubo cardiomyopathy (TTS) has long been considered a benign condition, despite recurrent events and long-term adverse outcomes are often reported. Endothelial damage, blood hyperviscosity, and platelet activation described in acute phase persist in long-term follow-up; however, TTS pathophysiology is still not fully understood. Here, we explored the hemostatic system at a median of 3.

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Migraine is a chronic neurovascular disease with a complex, not fully understood pathophysiology with multiple causes. People with migraine suffer from recurrent moderate to severe headache attacks varying from 4 to 72 h. The prevalence of migraine is two to three times higher in women compared with men.

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Background: Percutaneous closure represents the first line of treatment in patients with cryptogenic stroke and documented patent foramen ovale (PFO). Scarce data report the long-term outcomes of patients undergoing PFO closure with the Figulla Flex II device (Occlutech, Germany).

Methods: Consecutive patients undergoing PFO closure with a Figulla Flex II device at a single, high-volume Institution were included.

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Background: The ADVANTAGE study demonstrated in a cohort of stented patients a diagnostic accuracy of stress myocardial CT perfusion (CTP) significantly higher than that of coronary CT angiography (CCTA) for the detection of in-stent restenosis (ISR) or CAD progression vs. quantitative coronary angiography (QCA). This is a pre-defined subanalysis of the ADVANTAGE aimed at assessing the difference in terms of diagnostic accuracy vs.

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Background: Transradial approach for carotid artery stenting (TRCAS) is an established technique in specific anatomies potentially associated with high periprocedural event rate from femoral catheterization. The engagement of left common carotid artery originating from the aortic arch is the most challenging scenario requiring specific catheters and techniques.

Methods: Among 542 consecutive TRCAS 66 had left, non-bovine carotid stenosis as the target vessel.

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Early menopause is associated with an increased risk of cardiovascular diseases, including aortic stenosis (AS). We sought to investigate the prevalence and impact of early menopause on clinical outcomes in patients who underwent transcatheter aortic valve implantation (TAVI) for severe symptomatic AS. Women's International TAVI is a multinational, prospective, observational registry of women who underwent TAVI for severe symptomatic AS (n = 1,019).

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Periprocedural cerebral microembolization is the most important complication of carotid artery stenting. Among several variables that play a role to reduce this risk, brain protection (proximal vs. distal) plays a pivot role.

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Carotid artery stenting (CAS) is an established technique to treat carotid artery stenosis. Favorable results have been reported in different subsets of patients in both acute and long-term settings. Among the CAS periprocedural variables the type of cerebral protection - distal filter and proximal protection - play a pivot role to reduce cerebral embolization.

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Article Synopsis
  • This study looked at a method called transradial/brachial carotid artery stenting to help treat patients with blocked arteries in their necks.
  • The researchers treated 137 patients, most of whom were older men, and found that the procedure was mostly successful, with very few complications.
  • Only a small number of patients had strokes or complications, which means the method is considered safe and effective for high-risk patients.
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  • The study assessed in-hospital outcomes for nonagenarians (patients aged 90 and older) who underwent primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI) between 2009-2019.
  • Out of 308 patients, 32% experienced in-hospital death, with identified predictors including lower left ventricle ejection fraction (LVEF), lower systolic blood pressure (SBP), and lack of independence in daily activities.
  • The findings suggest that nonagenarian STEMI patients have a high mortality rate after pPCI, and maintaining independence in daily life is crucial for improving their chances of survival during hospitalization.
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Background: Transcatheter aortic valve implantation (TAVI) has become an accepted treatment for patients with severe aortic stenosis (AS). Predicting which patients are at risk for adverse clinical outcomes after TAVI remains difficult, especially in women.

Aim: To identify predictors of adverse events in the WIN-TAVI cohort.

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Background: Cardiac stress tests remain the cornerstone for evaluating patients suspected of having obstructive coronary artery disease (CAD). Coronary microvascular dysfunction (CMD) can lead to abnormal non-invasive tests.

Aims: We sought to assess the diagnostic performance of exercise stress tests with indexes of epicardial and microvascular resistance as reference.

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Background: Data on left main (LM) percutaneous coronary interventions (PCI) have mostly been obtained in studies using drug-eluting stent (DES) platforms without dedicated large-vessel devices and with limited expansion capability.

Aims: Our study aimed to investigate the safety and efficacy of LM PCI with the latest-generation Resolute Onyx DES.

Methods: ROLEX (Revascularization Of LEft main with resolute onyX) is a prospective, multicentre study (ClinicalTrials.

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