Publications by authors named "Daniela Steiner"
Article Synopsis
- Increased cell proliferation in acute lymphoblastic leukemia (ALL) is linked to genetic changes affecting prognosis, with telomere length (TL) and telomerase activity (TA) being key factors in assessing patient risk.
- In patients with ALL, lymphoblasts showed significantly shorter TL compared to normal B- and T-lymphocytes, and high-risk pediatric patients exhibited higher TA, indicating a potential correlation between TA and disease severity.
- The use of the telomerase inhibitor imetelstat demonstrated that it can effectively induce apoptosis in B-ALL cells in vitro, suggesting that targeting telomerase may enhance current treatments for ALL by helping to identify and treat high-risk patients.
