Publications by authors named "Daniela Spanu"
Nurses should have appropriate education and required competencies to provide high-quality palliative care. The aim of this international multisite study was to list and evaluate core palliative care competencies that European nurses need to achieve in their education to provide palliative care. The Nominal Group Technique (NGT) was used as a data collection method.
View Article and Find Full Text PDFThe worldwide prevalence of allergic disease is rising as a result of complex gene-environment interactions that shape the immune system and host response. Climate change and loss of biodiversity are existential threats to humans, animals, plants, and ecosystems. While there is significant progress in the development of targeted therapeutic options to treat allergies and asthma, these approaches are inadequate to meet the challenges faced by climate change.
View Article and Find Full Text PDFAllergen immunotherapy (AIT) is considered the only disease-modifying treatment available at present for allergic disorders. Its main benefits include improvement of symptoms, decreased need for pharmacotherapy, prevention of new sensitizations and sustained effect after AIT completion. The key pillars of AIT-induced tolerance include a shift from Th2 to Th1 response, an increase of regulatory T and B cells, pro-inflammatory effector cell downregulation and IgE suppression, in addition to IgG4, IgA and IgD induction.
View Article and Find Full Text PDFArticle Synopsis
- A precise diagnosis is crucial for effectively managing allergic diseases and asthma, but traditional methods with allergen extracts often miss the specific molecules causing reactions.
- Component-resolved diagnosis (CRD) addresses these limitations and is now a valuable tool in allergy clinics, helping differentiate between true sensitivities and cross-reactivity, predict severe allergic reactions, and tailor allergen immunotherapy.
- CRD represents a shift towards precision immunology, enhancing the management of allergic conditions by offering a more detailed understanding of patient sensitization profiles.
Purpose Of Review: Allergen immunotherapy (AIT) is a well-known disease-modifying intervention for allergic diseases. Its benefit in allergic asthma, ranging from prevention to facilitating asthma control, is yet to be clarified.
Recent Findings: In 2017, following several well-designed randomised controlled trials (RCTs) with house-dust mites (HDM) sublingual (SLIT) tablets in asthma, global initiative for asthma (GINA) guidelines highlighted the need to treat the allergic component of asthma.