Age-related efficacy of parathyroid hormone on osseointegration in the rat.

Objective: Aging is a physiological determinant that can distinguish the outcome of a pharmaceutical therapy to improve osseointegration of titanium implants. Here we examined the possible interaction of intermittent parathyroid hormone (PTH) and the age of the recipient on the parameters of osseointegration in a rat tibia implantation model.

Material And Methods: Twenty female Wistar rats aged 8 months and 20 female rats aged 2 months received PTH at 60 microg/kg body weight or a vehicle by a subcutaneous injection three times a week.