Publications by authors named "Daniela Rolph"
Teleost fishes and urodele amphibians can regenerate amputated appendages, whereas this ability is restricted to digit tips in adult mammals. One key component of appendage regeneration is reinnervation of the wound area. However, how innervation is regulated in injured appendages of adult vertebrates has seen limited research attention.
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- Osteoblast differentiation is significantly impaired in conditions like arthritis and osteoporosis; the study explores how ferutinin, a phytoestrogen, can help induce differentiation from dental pulp-derived stem cells (DPSC).
- The research highlights that ferutinin increases the expression of the transcription factor KLF2 and related autophagy molecules in DPSCs, showing KLF2's role in promoting both autophagy and osteoblast differentiation.
- Additionally, ferutinin treatment leads to improved mitochondrial function and reduced oxidative stress in DPSCs, supported by chromatin immunoprecipitation findings that indicate epigenetic modifications at the ATG7 gene promoter, enhancing autophagy processes.
Myocardial ischemia is a common manifestation of cardiovascular diseases (CVD) that affects the health and lives of millions of people worldwide. While numerous treatment options exist that address cardiac damage after ischemic injury, none of these can repair damaged cardiac tissue. Stem cell-mediated therapy is an emerging approach for cardiac tissue regeneration that has shown promise in preclinical models and in clinical studies.
View Article and Find Full Text PDFTranscriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2.
Front Immunol
April 2021
Dysregulation of osteoclastic differentiation and its activity is a hallmark of various musculoskeletal disease states. In this review, the complex molecular factors underlying osteoclastic differentiation and function are evaluated. The emerging role of KLF2 in regulation of osteoclastic differentiation is examined, specifically in the context of rheumatoid arthritis in which it has been most extensively studied among the musculoskeletal diseases.
View Article and Find Full Text PDFFerutinin directs dental pulp-derived stem cells towards the osteogenic lineage by epigenetically regulating canonical Wnt signaling.
Biochim Biophys Acta Mol Basis Dis
April 2020
Osteoporosis is a silent systemic disease that causes bone deterioration, and affects over 10 million people in the US alone. This study was undertaken to develop a potential stem cell therapy for osteoporosis. We have isolated and expanded human dental pulp-derived stem cells (DPSCs), characterized them, and confirmed their multipotential differentiation abilities.
View Article and Find Full Text PDFHypothesis: p21-activated kinase (PAK) regulates signaling pathways that promote cell survival and proliferation; therefore, pharmacological inhibition of PAK will induce cell death in vestibular schwannomas (VS) and meningiomas.
Background: All VS and many meningiomas result from loss of the neurofibromatosis type 2 (NF2) gene product merlin, with ensuing PAK hyperactivation and increased cell proliferation/survival.
Methods: The novel small molecule PAK inhibitors PI-8 and PI-15-tested in schwannoma and meningioma cells-perturb molecular signaling and induce cell death.