Publications by authors named "Daniela Rodriguez Rincon"
The ability to sequence and understand different variants of the SARS-CoV-2 virus and their impact is crucial to inform policy and public health decisions. Soon after the UK went into its first lockdown in March 2020, the CCOVID-19 Genomics UK (COG-UK) Consortium was launched. COG-UK is a collaboration of experts in pathogen genomics including academic institutions, public health agencies, the Wellcome Sanger Institute, NHS Trusts and Lighthouse Labs.
View Article and Find Full Text PDFPredictive genetic testing provides individuals with information about their future risk of developing health conditions. Theoretically, predictive genetic tests could have positive or negative impacts on the insurance industry. If genetic test results stimulate actions to reduce health risks, they may reduce costs to insurers.
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- The study investigates the effects of roscovitine, a drug that inhibits cyclin-dependent kinases, on persistent neutrophilic inflammation in cystic fibrosis (CF), which is driven by chronic pulmonary infections.
- Roscovitine was tested using zebrafish larvae with CF, alongside murine and human models, showing it reduces harmful neutrophil activity and promotes inflammation resolution, but its effectiveness varies across different models.
- While it enhances bacterial killing in human CF macrophages, in animal models, roscovitine led to worsened infections by disrupting immune responses, suggesting careful consideration is needed for its therapeutic use in CF.
Although almost all mycobacterial species are saprophytic environmental organisms, a few, such as , have evolved to cause transmissible human infection. By analyzing the recent emergence and spread of the environmental organism through the global cystic fibrosis population, we have defined key, generalizable steps involved in the pathogenic evolution of mycobacteria. We show that epigenetic modifiers, acquired through horizontal gene transfer, cause saltational increases in the pathogenic potential of specific environmental clones.
View Article and Find Full Text PDFNew therapeutic approaches are needed against , a respiratory mycobacterial pathogen that evades efforts to successfully treat infected patients. Clofazimine and bedaquiline, two drugs used for the treatment of multidrug-resistant tuberculosis, are being considered as alternatives for the treatment of lung diseases caused by With the aim to understand the mechanism of action of these agents in , we sought herein to determine the means by which can develop resistance. Spontaneous resistant strains selected on clofazimine, followed by whole-genome sequencing, identified mutations in , encoding a putative TetR transcriptional regulator.
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- Lung infections caused by Mycobacterium abscessus, a multidrug-resistant mycobacteria, pose a significant threat to individuals with cystic fibrosis as they worsen lung damage and increase health risks.
- Contrary to previous beliefs that these infections are acquired from the environment, recent genomic analysis shows many cases are actually spread through transmission from person to person, possibly via surfaces and aerosols.
- The analysis also identified that dominant circulating clones of M. abscessus are linked to worse health outcomes and higher virulence, indicating an urgent global health challenge.